Efficacy and safety of immune checkpoint blockade for brain metastases
نویسندگان
چکیده
منابع مشابه
Combined irradiation and targeted therapy or immune checkpoint blockade in brain metastases: toxicities and efficacy.
Background Targeted therapies (TT) and immune checkpoint inhibitors (ICI) are currently modifying the landscape of metastatic cancer management and are increasingly used over the course of many cancers treatment. They allow long-term survival with controlled extra-cerebral disease, contributing to the increasing incidence of brain metastases (BMs). Radiation therapy remains the cornerstone of B...
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Increased numbers of tumour infiltrating T‑cells have long been associated with a better prognosis in ovarian cancer, which has led to the general assumption of a relevant impact of T‑cellular anti-tumour immunity in this disease. As a consequence of this knowledge, a multitude of immunologic therapies has emerged over the past years. Although some reports could evidence a successful induction ...
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BACKGROUND Severe myocarditis associated with electrical conduction abnormalities and occasionally heart failure has been well documented following treatment with immune checkpoint blockade with an estimated incidence of less than 1%. However, the incidence, early detection, and management of less severe immune-related myocarditis are unknown since most immunotherapy trials have not included ro...
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ژورنال
عنوان ژورنال: CNS Oncology
سال: 2019
ISSN: 2045-0907,2045-0915
DOI: 10.2217/cns-2018-0018